Piroxicam-induced hepatic and renal histopathological changes in mice

Piroxicam-induced hepatic and renal histopathological changes in mice

UNLABELLED Piroxicam is a non-steroidal anti-inflammatory drug widely used in rheumatic diseases. The aim of this study was to investigate Piroxicam-induced histopathological changes in livers and kidneys of male albino mice. METHODS Animals were classified into a control group and 4 treated groups. Piroxicam was injected intraperitoneally using 0.3 mg/kg every day for four weeks. Each week a...

Diosmin Attenuates Methotrexate-Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice

The current study was designed to investigate the beneficial role of diosmin, a biologically active flavonoid, against methotrexate- (MTX-) induced hepatic, renal, and cardiac injuries in mice. Male Swiss albino mice received a single intraperitoneal injection of MTX (at 20 mg/kg, body weight) either alone or in combination with oral diosmin (at 50 or 100 mg/kg body weight, for 10 days). Serum ...

Crataegus monogyna extract on renal histopathological changes in diabetic rats

Renal complications is considered as important cause of mortality in diabetic patients. This study investigated the effect of hydroalcoholic extract of C. monogyna on renal histopathological changes in diabetic rats. In this experimental study 40 male Wistar rats were divided into 5 groups (n=8) including control (receiving normal saline), diabetic (receiving streptozotocin), treatment groups ...

Nimesulide induced histopathological changes in the vas deferens of mice.

AIM Nimesulide, a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1. COX-2 selective inhibitors cause frequent nephrotoxicity and hepatotoxicity following their usage. This proposes a physiological role of COX-2 in kidney and liver. Not much attention has been focused on the role of COX-2 with respect to reproduction especially in male reproduction, and...

Piroxicam-induced acute renal failure (anuria)